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Professor John Brazier

Professor of Health Economics

Key Areas of Expertise:

Development of preference based measures

Measuring and Valuing Health

Health Economics

John Brazier was awarded a Personal Chair in Health Economics in 1999. He has more than 20 years experience of conducting economic evaluations for policy makers. John’s main interests have been in the measurement and valuation of health for economic evaluation, including the development of preference-based measures of health from the SF-36 and a number of condition specific measures. John has published widely in the area (over 150 papers and a book published by OUP).

Research interests

SF-6D preference-based index

  • Developed by Brazier et al (2002). Syntax files available from
  • International valuation studies in Japan, Hong Kong, Portugal, Brazil, Australia and Singapore
  • Comparisons to other generic preference-based measures

Deriving preference-based measures from condition specific measures

  • Published studies: Kings Health Questionnaire, Atopic Dermatitis in Children, Menopausal specific health related quality of life questionnaire, Asthma Quality of Life Questionnaire, Overactive Bladder Questionnaire, Sexual Functioning Questionnaire.
  • Current studies: Dementia Quality of Life (DEMQoL), Epilepsy QoL battery.

Modelling preference data

  • Applying Bayesian methods to estimating preference-based algorithms
  • Estimating health state values from ordinal data (rank and DCE)

Validity of EQ-5D across medical conditions.

Mapping from condition specific and other generic measures onto EQ-5D

  • Recent and ongoing trial based economic evaluations: Complementary therapy (YACBAC trial), treatments for varicose veins, computerised cognitive behavioural therapy in MS, Borderline Personality Disorder (SPeDi trial)
  • Model based economic evaluations: computerised cognitive behavioural therapy (NICE), Dialectical behavioural therapy for Borderline Personality Disorder (HTA)

Examining the relationship between health and well-being (and the role of adaptation)

Professional activities

  • NIHR Senior Investigator award 2009-2013
  • The estimation of a preference-based single index measure for health from the SF-36. Journal of Health Economics 2002; 21(2): 271-292 was ‘Article of the Year”, International Society of Quality of Life, 2002 and listed as a Thompson Essential Scientific Indicators Special Topic on Fast Moving Fronts in Economics and Business.
  • Associate editor for ‘Quality of life Research’ from 2006-2010 and ‘Applied Health Economics and policy’ from 2003
  • Member of the Fellowship Panel of the MRC Public Health and Health Services Research Board until 2010
  • ScHARR Director of Research

Current projects

  • Preparatory Study for the Re-evaluation of the EQ-5D Tariff (PRET)
    Co-investigator (PI: Aki Tsuchiya)
    Medical Research Council £280,000 (2010-2012)
  • Use of generic and condition-specific measures in NICE decision-making
    Co-investigator (PI: Louise Longworth)
    Medical Research Council £280,000 (2010-2012)
  • Assessing the impact of children with ADHD on the health and wellbeing of their families
    Principal Investigator
    Shire Pharmaceuticals Limited £597,146 (2009-2011)